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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EPHB4 All Species: 13.33
Human Site: S642 Identified Species: 32.59
UniProt: P54760 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54760 NP_004435.3 987 108270 S642 K A P G K K E S C V A I K T L
Chimpanzee Pan troglodytes P0C0K6 1020 110674 R685 G S F G E V R R G R L Q P R G
Rhesus Macaque Macaca mulatta XP_001097522 1001 110812 V663 K Q P G R R E V F V A I K T L
Dog Lupus familis XP_546948 1000 109917 S655 K A P G K K E S C V A I K T L
Cat Felis silvestris
Mouse Mus musculus P54761 987 108904 S642 K A P G K K E S C V A I K T L
Rat Rattus norvegicus P09759 984 109865 I646 K L P G K R E I Y V A I K T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001521846 981 107213 S635 K A P G K K E S Y V A I K T L
Chicken Gallus gallus Q07498 988 109560 I650 K L P G R R E I F V A I K T L
Frog Xenopus laevis Q91735 974 108246 Q636 K Q A G R R E Q F V A I K T L
Zebra Danio Brachydanio rerio O13146 981 109636 C641 A G E F G E V C S G R L R L P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 43.2 58.4 95.5 N.A. 92.7 56.7 N.A. 87.4 57.5 56 50.3 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 60.9 72.1 96.6 N.A. 95.6 71.8 N.A. 91.4 72.3 72.7 67.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 66.6 100 N.A. 100 73.3 N.A. 93.3 66.6 60 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 20 80 100 N.A. 100 80 N.A. 93.3 80 73.3 20 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 40 10 0 0 0 0 0 0 0 80 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 30 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 10 0 10 10 80 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 10 10 0 0 0 0 30 0 0 0 0 0 0 % F
% Gly: 10 10 0 90 10 0 0 0 10 10 0 0 0 0 10 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 20 0 0 0 80 0 0 0 % I
% Lys: 80 0 0 0 50 40 0 0 0 0 0 0 80 0 0 % K
% Leu: 0 20 0 0 0 0 0 0 0 0 10 10 0 10 80 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 70 0 0 0 0 0 0 0 0 0 10 0 10 % P
% Gln: 0 20 0 0 0 0 0 10 0 0 0 10 0 0 0 % Q
% Arg: 0 0 0 0 30 40 10 10 0 10 10 0 10 10 0 % R
% Ser: 0 10 0 0 0 0 0 40 10 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 80 0 % T
% Val: 0 0 0 0 0 10 10 10 0 80 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 20 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _